Epistaxis from Idiopathic Internal Carotid Artery Aneurysm

and after oral GC therapy (GC-treated) and 8 controls of inferior turbinate mucosa were included. cDNA microarray analysis, together with histoand immunohistochemical validation, was performed. RESULTS: Infiltration of eosinophils and neutrophils was prominent in GC-nave NP. GC was effective in reducing the recruitment of both nasal mucosal eosinophils and neutrophils. Thirty-one eosinophil-associated genes were differentially expressed in GC-nave NP versus control. Expression of five genes (MMP9, NR4A1, NR4A2, CD69 and DUSP1) demonstrated a significant change after GC treatment. On the other hand, expressions of 14 neutrophil-associated genes were different in GC-nave NP versus control and 3 of them (MMP7, MMP9 and CXCL2) were responsive to GC therapy. Immuno-staining showed the co-localization of MMP7 and MMP9 with neutrophils and the decrease of these proteins in NP after GC treatment. NR4A1/NR4A2 proteins were absent in eosinophils from all GC-nave NP but present in some GC-treated NP. CONCLUSION: GC is effective in inhibiting both eosinophil and neutrophil infiltration in NP, which can be demonstrated by modulation of those important eosinophiland neutrophilassociated genes.